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& Collins, J.J

Similarly, inhibition of PI3K/Akt signalling, which extends lifespan in model organisms, also prevents chemotherapy-induced ovarian depletion (Kalich-Philosoph et al, 2013)

This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

Individuals with lower baseline levels often require structured daily support to rebuild reserves

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