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DHODH inhibitors: what will it take to get them into the clinic as antivirals

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These phase I oxidative reactions metabolise 210% of paracetamol to a reactive intermediate, N -acetyl- p -benzoquinone imine (NAPQI) which mediates the hepatotoxic effect of paracetamol

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Glycopyrrolate cream at a concentration of 0.5% is topically applied to reduce sweating by blocking acetylcholine receptors in sweat glands, thereby decreasing perspiration