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Acknowledgements This work was supported by project number 2020/39/B/NZ9/01894 from the National Science Centre (NCN), Poland and by the project number WZ/WB-II/2/2023 from the Ministry of Science and Higher Education.The authors are very grateful to Professor Shimshon Belkin, Dr Tal Elad, Dr Liat Moscovici and Dr Sharon Yagur-Kroll, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel for providing bacteria strains

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SIRT3 knockdown induces energy metabolism and mitochondrial respiration in GBC cells, but reduces ROS production and ACSL4 expression, and inhibits AKT-dependent ferroptosis

J Appl Toxicol 23(4):263

Therefore, it can be proposed that the underlying mechanisms of sildenafils protective effects against CP-induced liver injury are associated with its antioxidant potential through its capacity to prevent cGMP degradation