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E-cigarettes can damage cells related to innate and adaptive immunity in the respiratory tract, resulting in abnormal mucus composition, reduced epithelial barrier function, impaired phagocytic function, and elevated systemic inflammatory markers (especially type 2 inflammatory cytokines IL-4, IL-5, IL-13)
2023 titled Prevention of Tobacco Use in an Adolescent Population Through a Multi-personal Intervention Model. What Is the Link Between Nicotine Addiction and Other Substance Use Disorders
Most tobacco use, including vaping, starts and is established during adolescence