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Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

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The incidence typically rises as your dose increases over the first 23 months of treatment, then often stabilizes or improves as your body adapts

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Cells acquire cysteine mainly by macrophage and lymphocyte uptake, and impaired immune responses are associated with a reduction in GSH concentration (Drge and Breitkreutz, 2000

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doi: 10.1146/annurev.immunol.23.021704.115835 211 JongeriusIPorcelijnLvan BeekAESempleJWvan der SchootCEVlaarAPJet al

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