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CagriSema takes the combination approach -- pairing two proven molecules (semaglutide and cagrilintide) in a single injection that produced 20.4% weight loss in phase 3, with 60% of patients losing 20% or more

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Overweight or obesity (BMI 30-plus, or 27-plus with a weight-related condition) where weight loss is the goal and there is no diabetes driving the choice

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First, KEAP1 has been shown to have complex interactions with various other proteins besides NRF2 (Hushpulian et al., 2021) and concerns about potential side effects arise from the diverse array of cellular processes covered by KEAP1 interactor proteins, involving DNA replication, cytoskeletal dynamics, transcription, and apoptosis