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In the heart under pressure overload, intracellular copper accumulation can trigger cardiomyocyte cuproptosis via FDX1 activation, leading to lipoylated protein aggregation and mitochondrial damage, thereby exacerbating cardiac injury [12]

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At The Center for Occupational and Environmental Medicine (COEM), intravenous administration is considered when laboratory findings, exposure history, or clinical presentation suggest increased oxidative burden or impaired detox capacity

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The treatment itself typically lasts around 15 minutes