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Description

The in-vivo data are overwhelmingly rodent

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The compound buthionine sulfoximine (BSO, Figure 2D) can induce ferroptosis in retinal pigment epithelium by inhibiting glutamate-cysteine ligase (GCL), a rate-limiting enzyme in de novo GSH synthesis (Sun et al., 2018)

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Copper peptides are generally well-tolerated with minimal side effects

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In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside and/or a saccharide alkyl ester

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