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This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur

"Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase"

It depends on your goals and diet

Adding 2 mL of BAC water to a 5 mg vial (2,500 mcg/mL) is a popular choice for easy measurement

10.1159/000346968 [DOI] [PubMed] [Google Scholar] EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) (2015)