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Factors Influencing the Effectiveness of Vitamin B12 Shots Several factors can influence how quickly and effectively a Vitamin B12 shot works: Severity of Deficiency : Individuals with severe Vitamin B12 deficiency may experience a more noticeable and rapid improvement in symptoms compared to those with mild deficiency

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, et al

However, the pills must be taken on an empty stomach in order to be properly absorbed, which can be a challenge for some people

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