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Research published in the journal Andrology indicates that the accumulation of lead (Pb) and cadmium (Cd) in seminal plasma due to smoking correlates with reduced sperm count and motility

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Nicotine upregulates its own receptors through enhanced intracellular maturation

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As a result, Altria may not make any claims that IQOS is safer than cigarettes, may not advertise on radio or television, and may add only menthol rather than the variety of flavors sold in other countries as flavoring