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Metformin, known for its multifaceted beneficial properties, is acknowledged for its ability to counteract the adverse effects of increased oxidative stress at both molecular and cellular levels
Additionally, the small amount of cell material employed, in particular for the tumoral model (500 cells/microtissue), could enable personalized drug testing in clinical settings using scarce primary material from biopsies without the need of time-consuming ex vivo cell expansions
DNA fragmentation has a direct impact on sperm function and male fertility
Intracellular signal pathways are involved in numerous biological processes and have also been demonstrated to be intimately linked to the development of drug resistance
doi: 10.2174/1570159X13666160502153022
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