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It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose
Moreover, NPs offer the advantage of multitarget and multipathway interactions, allowing them to regulate Nrf2 from various angles, thereby exerting anti-inflammatory and antioxidant effects
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The sample size was calculated based on the obesity prevalence of 20% in Kuwaiti adolescents for a casecontrol study, to detect a similar odds ratio with 90% statistical power and a 5% margin of error
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