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long-term use can cause significant adverse effects including kidney problems, hypertension, and non-melanoma skin cancers (Paul 2003

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When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications

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[DOI] [PubMed] [Google Scholar] 43.Tanimoto K, Khoury B, Feng K, Cavanaugh JM