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While it is highly unusual for a 100 kilodalton pathogen effector to be translocated to the host cell cytoplasm (GS-like effectors are obligate homo-dimers of 50 kDa per subunit, S4 Fig), plant parasitic nematodes clearly have the ability to construct organelle-sized structures inside the host cell at the plasma membrane where it meets the stylet orifice (reviewed in [32])

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Sepesi B, Swisher SG Hofstetter WL , Rice DC, Roth JA, Walsh GL, Mehran RJ, Vaporciyan AA

Many peptides degrade rapidly in the acidic environment of the stomach, but BPC-157 has demonstrated significant resistance to enzymatic breakdown in gastrointestinal models