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Melatonin regulates the transcription of APP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells

Fibroblast-like synoviocytes (FLSs) contribute to pannus formation and matrix degradation through MMP-1 and MMP-3, with expression levels 5 - 10 times higher in RA synovium (Figure 1) (14)

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Increased levels of TNF- can be found in the colon, blood, and feces of UC patients