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We hypothesized that glutathione supplementation may preferentially benefit distinct cirrhosis phenotypes with active systemic inflammation

Kikuchi, G., Motokawa, Y., Yoshida, T

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Discussion The present study demonstrated that stimulation with the Sirt1 agonists Res or SRT could suppress the microglial activation and apoptosis, reduce inflammation, trigger Gli-1 translocation from the cytoplasm to the nucleus and upregulate the protein expression levels of Shh, Ptc-1, Smo and Gli-1 following OGD/R in vitro