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EGCG as a chemopreventive agent can modulate angiogenesis and apoptosis by downregulation of various signaling pathways such as Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor Receptor (EGFR) and cell cycle regulatory proteins such as Mitogen-activated protein kinases (MAPK) (Shankar et al

These changes were accompanied by marked downregulation of junctional proteins zonula occludens-1 (ZO-1), Ecadherin, and occludin ( in vitro findings link ferroptotic signaling to impaired intercellular adhesion and increased epithelial permeability, suggesting a plausible mechanism for enhanced bacterial translocation into deeper periodontal tissues in vivo

Metastasis is mainly responsible for treatment failure and is the cause of most breast cancer deaths

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