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Therapeutically, small trials in humans are underway: one randomized trial in mild AD is testing an oral broad-spectrum antibiotic followed by FMT to reset the microbiome [142]
In addition to the canonical molecules in the Wnt/-catenin signalling pathway mentioned above, many other molecules also affect the signal transduction of the Wnt/-catenin signalling pathway
In general, three different groups of agents were described in the past: (i) mAbs, either targeting the ligand HGF or the receptor Met, (ii) tyrosine kinase inhibitors, targeting the tyrosine kinase domain of Met (and mostly also the TK domain of other RTKs), (iii) a truncated, soluble Met receptor serving as decoy for HGF (44) and the competitive HGF antagonist NK4 (18)
8, 9 Enteric short-chain fatty-acids, such as propionic acid (PPA), 10, 11, 12, 13, 14, 15, 16, 17 which are fermentation by-products of ASD-associated enteric bacteria (that is, Clostridia, Desulfovibrio, Sutterella and Bacteroidetes ), have been suggested as a possible environmental triggers in ASD
Peptide-based skin support
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