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In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

: Visible results without microdermabrasion tools

When research on a particular compound comes almost exclusively from one geographic region and institutional network, there is inherent risk of confirmation bias, methodological preferences that favor positive findings, and results that may not generalize to other populations or research contexts

"Intracerebral hemorrhage triggers the brain HGF-MET pathway to protect neurons from apoptotic death." Stroke

Its also important to remember that even with treatment, it may take weeks or even months before you see results