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Tesamorelin activates GHRH receptors in the pituitary to increase GH pulse amplitude (the amount released per pulse), while Ipamorelin activates ghrelin receptors to increase pulse frequency (the number of pulses per day)

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In all early-stage clinical studies of IGF-1R therapeutics, there were always a few patients for whom there was substantial and long-lasting benefit, whetting the appetite for additional study