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The imbalance between ubiquitination and deubiquitination may be associated with the pathogenesis of a variety of diseases, including tumors[91], hematologic disorders[92], and neurodegenerative diseases[93]

doi: 10.1186/1742-2094-9-158

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This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles

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