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This blockage of the blood and lymph vessels causes the physical manifestations of inflammation, namely redness, pain, stiffness, lack of mobility, and swelling

TAp73 enhances lactate metabolism through upregulation of PFKL (phosphofructokinase-1, liver type) and serves as a crucial upstream regulator in the mechanisms of lactate accumulation and lactate-associated tumor adaptation, making it an important molecular node linking tumor metabolic reprogramming to lactate accumulation [202]

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2023a, b