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Mechanisms of ADE ADE has been documented to occur through two distinct mechanisms in viral infections: by enhanced antibody-mediated virus uptake into Fc gamma receptor IIa (FcRIIa)-expressing phagocytic cells leading to increased viral infection and replication, or by excessive antibody Fc-mediated effector functions or immune complex formation causing enhanced inflammation and immunopathology (Fig

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The GARD model was subsequently validated in additional studies across different cancer types [84,85,86], including triple-negative breast cancer [84]

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition