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Scanning for new evidence on riboflavin to support a dietary reference intake review

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In the absence of adequate GPX4, the radical intermediates, readily produced from hydroperoxy-phospholipids, directly oxidize GSH in a 1-electron reaction to generate a strongly pro-oxidant radical, GSH

2 GPX family and oxidative stress 2.1 GPX1 Glutathione peroxidase 1 (GPX1) was first identified in 1957 as a red blood cell enzyme that protects hemoglobin from oxidative stress ( 2 O 2 and soluble low-molecular hydroperoxides, but not with more complex lipid hydroperoxides

10.3390/ijms22073603 33 GabbyM.TauberM.PoratS.SimantovR