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DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

ii) Anti-inflammatory and anti-fibrosis therapy should be considered in some patients with cirrhosis for whom etiological therapy is not available, or for whom liver inflammation or fibrosis remains severe after etiological therapy

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