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In human females, blood GSH drops after ovariectomy from 54.69 to 39.29 nmol/L, but is restored by estrogen replacement therapy [1]

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The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]

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Understanding why this occursfrom metabolic adjustment and nutrient demands to injection site reactionshelps distinguish expected responses from complications requiring medical attention