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This dual push-pull is why the IGF-1Akt axis is considered a master regulator of muscle mass, although its exact role in the adult muscle response to mechanical load is, by the authors own account, less clearly defined than its role in development and regeneration

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We first isolated stromal vascular fraction (SVF) and adipocyte fraction from iWAT of Gpr146 +/+ and Gpr146 / mice fed with HFD for 3 months and assessed their gene expression profiles