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NAD+ helps control mitochondrial quality by activating SIRT1, which then activates PGC-1the key controller of mitochondrial biogenesis

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At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance