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have discovered that after continuous oxaliplatin stimulation, p53 ubiquitination was enhanced and its stability was damaged, thus inducing oxaliplatin resistance in CRC (161)

10.1016/j.vetimm.2009.01.005

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n=140) and a preceding proof-of-concept, open-label study (n=113) collectively indicated that metformin can reduce prednisone exposure and may lower the risk of disease relapse, particularly major flares (250, 251)