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Although NGF infusion in the brain showed slight cognitive improvements in AD patients, long-term administration of NGF through ICV was associated with serious side effects, such as hyper-innervation of cerebral blood vessels [47], hypophagia [48] and neuropathic pain [46]

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Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus