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Freezing causes ice crystal formation that physically disrupts peptide chains

10.1097/MD.0000000000034728 309 YeM.ChungH.-S.LeeC.Hyun SongJ.ShimI.KimY.-S.et al (2016a)

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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

Early research connected the peptide to gastric-protection models, while later studies expanded into musculoskeletal, vascular, neurological, dermatological, and systemic research areas