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Long-term use can lead to hepatitis, liver tumors, and cirrhosis

2016;30(S1):690.17-690.17

The KO mice, which are deficient for the transcription factor RAR-related orphan receptor alpha ( Rora) in hematopoietic and endothelial cells, exhibit an almost complete absence of steady-state pulmonary IL-5 + and IL-13 + ILC2s (Kindermann et al, 2020

doi: 10.1111/pce.13602 28 HanY.ChaouchS.MhamdiA.QuevalG.ZechmannB.NoctorG

In particular, it was observed that either phase shifts in the light-dark schedule or manipulated photoperiods may promote the initiation and advancement of mammary tumors 42,43,44