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Amid this chaos, astrocytes diverge into functionally opposing phenotypes: cytotoxic A1-reactive astrocytes secrete MMP-9 and ROS, actively eroding the neurovascular unit, while reparative A2 astrocytes deploy Wnt/-catenin signaling and TLR4-mediated neurotrophin release to facilitate synaptic rewiring and functional reorganization [154, 155]

Wawrzyski et al., 2006)