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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH

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Days 4 to 6: Stable therapeutic levels

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Particularly antibodies targeting IL-6 and IL-23 were significant even after correcting for somatic symptom improvement