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[31] Repeated exposure to nicotine can cause an increase in the number of nicotinic receptors, which is believed to be a result of receptor desensitization and subsequent receptor upregulation

It essentially means that upon making attempts to stop, one experiences physical and mood-related symptoms, such as anxiety, strong cravings, irritability, lack of concentration, restlessness, depressed mood, rage, frustration, increased hunger, insomnia, constipation, or diarrhea

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