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Ginsenoside Rg5 exhibits soft-acting effects on gene expression of neuronal cells in a wide range of physiological concentrations and a strong reversal impact at high (toxic) concentrations: significant up- or downregulation of expression of about 300 genes at concentrations from 10 6 M to 10 18 M, and dramatically increased both the number of differentially expressed target genes (up to 1670) and the extent of their expression (fold changes compared to unexposed cells) at a toxic concentration of 10 4 M

Senile osteoporosis (elderly rat model) Experimental Design: Animal: 24 month old male Wistar rats (aged osteoporosis model)