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Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death
The endoplasmic reticulum (ER) utilizes oxidizing environment for the formation of the disulfide bonds required for the folding of proteins into functionally active forms (Malhotra and Kaufman, 2007)
Consequently, disruptions in GSH biosynthesis, utilization, or recycling are hallmarks of oxidative stress and have been implicated in the pathogenesis of aging, neurodegenerative diseases like Parkinsons and Alzheimers, cancer, and various metabolic disorders [37]
Preclinical observations in animal and cell culture studies have included enhanced cellular migration, increased markers of angiogenesis, and enhanced collagen deposition