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In the case of organic compounds, biotransformation steps are often necessary and their nature, mechanism(s), responsible enzymes and related polymorphisms are well characterized and the respective role in determining individual sensitivity to the effects of exposure at different levels is a well-established field of investigation

doi: 10.1021/ac020050h 12 GallagherC

possibly because participants in the study were already on a cholesterol-lowering diet

[25] The form of plasticity known as long-term potentiation takes place at glutamatergic synapses in the hippocampus, neocortex, and other parts of the brain