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Many diseases including hypertension, diabetes, cardiovascular disease, and metabolic syndrome are associated with low levels of VD

vivax mono-infection, parasitemia higher than 1,000 parasites/l, and absence of any antimalarial treatment in the last 60 days

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IC 50 values were determined by non-linear least-squares fitting of a 4-parameter dose-response curve to collected data points (Graphpad Prism 7.0