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Other variants include energy-boosting, melatonin and slimming patches, reflecting a broader shift toward functional, lifestyle-driven products

In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

Free Radic Biol Med 19(2):169176

It also raises the possibility that FSP1 inhibitors may disrupt multiple parallel antioxidant systems, potentially enhancing therapeutic efficacy in oxidative stress-dependent pathologies, including cancer and degenerative diseases

Auld DS, Mennicken F, Quirion R