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But excessive use of nicotine can lead to other side effects, such as headaches, nausea, and appetite suppression

anti-smoking propaganda from the late-19th century and early-20th century

As one review stated, Nicotine is the addictive chemical in tobacco smoke, but its involvement in smoking-related harm (outside pregnancy) is very small, if any, compared to cigarette smoking. Another systematic review pointed out that nicotine can have a variety of potential health effects, from raising ones cardiovascular risk to causing birth defects in pregnant women

Reynolds Tobacco Company for Vantage 100s cigarettes (Imagine

There are more than 246 million cigarette smokers in Southeast Asia, where campaigners say low prices help make it one of the largest tobacco-consuming regions in the world