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The identification of specific, mutation-dependent metabolic vulnerabilities in particular cancers by targeting them to synergize with radiotherapy, chemotherapy, or immunotherapy to induce cytotoxicity is suggested

While B12 can be obtained through diet, some individuals may have difficulty absorbing it properly, leading to a deficiency

The present study observed reduced expression of 25-hydroxylase enzymes and 1--hydroxylase, vitamin D receptor, and increased expression of the 24-hydroxylase enzyme in the livers of HFD-fed mice

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Larger, placebo-controlled, biomarker-guided trials are needed to clarify efficacy, mechanisms, and optimal microbial strains