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Abbreviations ATP: Adenosinetriphosphate CADD: Computer aided drug design CDI: Carbonyldiimidazole DIPEA: N, N-diisopropylethylamine DMF: Dimethylformamide GDP: Guanosinediphosphate GN: Guanosine nucleotide GppNHp: Guanosine-5-[(,)-imido]triphosphate GST: Glutathione-S-transferase GTP: Guanosinetriphosphate KRAS: Kirsten rat sarcoma MD: Molecular dynamics MS: Mass spectrometry RBD: Ras binding domain SOS: Son of sevenless SWIIP: Switch-II-pocket References Scheffzek, K

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10.1002/cam4.2108 112 XiaofeiJ.MingqingS.MiaoS.YizhenY.ShuangZ.QinhuaX.et al (2021)

Erythrocytes from knock-out mice that do not express the energy-sensing enzyme AMPK are significantly more susceptible to the eryptotic effect of energy depletion than erythrocytes from wild-type littermates expressing normal levels of AMPK [149]