3,4,5 These symptoms are likely due to the effects of increased production of neurotransmitters dopamine, norepinephrine, acetylcholine, and serotonin, 4,6 which act on the locus coeruleus, ventral tegmental area, and nucleus accumbens
Despite the oral group receiving higher cumulative doses
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Although previous studies have used nano-fluorescent probes to detect the cellular delivery efficiency of oligonucleotide molecules, 403,457,575 more pharmacokinetic data on biodistribution, immune compatibility, and toxicity are needed for clinical translation and practical therapeutic application of these systems