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The collapse of m not only reflects impaired electron transport and ATP synthesis but also serves as a molecular trigger for mitochondrial dysfunction and downstream apoptotic signaling ( ROS further promote the pathological opening of the mitochondrial permeability transition pore (mPTP), leading to m collapse, matrix swelling, inner membrane rupture, and the release of pro-apoptotic factors such as cytochrome c

When youre targeting a disease like lung cancer, something thats a death sentence for a lot of people, you know it should be possible to diagnose it at an early stage, before symptoms manifest, by simply going after the right biomarker, Chan said

Exceptions sometimes exist for scars causing functional problems or significant psychological distress

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