Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020
308,309,310,311,312 This may be explained by the fact that an increased risk of HF may be related to fluid retention, which suggests that this change is reversible
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Epub 2016 Jul 4
Funding This review was supported by Grants from the National Natural Science Foundation of China (82101342 to LQ), Science and Technology Innovation Program of Hunan Province (2021SK53501 to HZ), Horizontal research Project (02220141 to HZ), and Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University