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Formation of reactive metabolites: Many hepatotoxicants like carbon tetrachloride [59], amodiaquine [60], acetaminophen [61], halothane [42], isoniazid [62,63] allyl alcohol and bromobenzene are metabolically activated to chemically reactive toxic metabolites which can covalently bind to crucial cellular macromolecules thus inactivating critical cellular functions [6]

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156 utilized ZIP6 residues 240253 (ZIP6-Y) and ZIP10 residues 4659 (ZIP10B) to target ZIP6 and ZIP10, preventing their heteromer formation and thereby impeding the progression of mitosis

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