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This may contribute the COPD pathology, inducing apoptosis, tissue damage as well as airway inflammation, since airway epithelial cells respond to increased ROS levels by producing cytokines/chemokines that attract inflammatory cells to the area of damage [5, 6, 21, 23, 24]

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However, it does not detract structurally or visually from the item, and I think it has very little impact on its value

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