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SSRP Institute

FOXO4-DRI alleviates testosterone secretion insufficiency in naturally aged mice

Human evidence remains confined to topical cosmetic work, including a 12-week trial in 71 women using formulations in the 0.11% concentration range applied to skin [5]

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

TB-500 is commonly studied for broader structural and actin-related pathway responses